Identification and Expansion of an Adaptive Natural Killer Cell Subset Present in Cord Blood
نویسندگان
چکیده
منابع مشابه
THE CYTOTOXICITY PATHWAY OF NATURAL KILLER CELLS IN CORD BLOOD COMPARED TO P ERIPHERAL BLOOD
The cytotoxic activity of natural killer cells is usually tested by radioactive assay CSI Cr release assay), which detects the release of cytoplasmic contents after plasma membrane disintegration of dying cells. In contrast to this indirect evaluation of cytotoxicity, the assessment of cell damage by flow cytometry aims to provide a more exact characterization of the death pathway via detec...
متن کاملHuman CD56dimCD16dim Cells As an Individualized Natural Killer Cell Subset
Human natural killer (NK) cells can be subdivided in several subpopulations on the basis of the relative expression of the adhesion molecule CD56 and the activating receptor CD16. Whereas blood CD56brightCD16dim/- NK cells are classically viewed as immature precursors and cytokine producers, the larger CD56dimCD16bright subset is considered as the most cytotoxic one. In peripheral blood of heal...
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Background: The mammalian target of rapamycin (mTOR) is important in hematopoiesis. Despite the central role of mTOR in regulating the differentiation of immune cells, the effect of mTOR function on cord blood mononuclear cells is yet to be defined. Objectives: To evaluate the effect of mTOR inhibition, using rapamycin on the proliferation and apoptosis of cord blood mononuclear cells, as well ...
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Department of Microbiology and Immunology and Cancer Research Institute, Division of Experimental Medicine, Department of Medicine, and Division of Infectious Diseases, University of California, San Francisco, CA 94143; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305; R&D Systems, Minneapolis, MN 55431; Departments of Laboratory Medicine and Medicine and Divi...
متن کاملExpansion of a unique CD57⁺NKG2Chi natural killer cell subset during acute human cytomegalovirus infection.
During human CMV infection, there is a preferential expansion of natural killer (NK) cells expressing the activating CD94-NKG2C receptor complex, implicating this receptor in the recognition of CMV-infected cells. We hypothesized that NK cells expanded in response to pathogens will be marked by expression of CD57, a carbohydrate antigen expressed on highly mature cells within the CD56(dim)CD16(...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 2016
ISSN: 1083-8791
DOI: 10.1016/j.bbmt.2015.11.503